опять 25
только встал, а уже 884 ;)
Showing posts with label блог. Show all posts
Showing posts with label блог. Show all posts
Sunday, June 18, 2023
Saturday, June 17, 2023
albums
получил сегодня, теперь становятся понятными, статистические выверты, предприянтые командой:
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Friday, June 16, 2023
Wednesday, June 14, 2023
something happened this spring
что-то случилось этой весною летом
13724 было в ноябре 2020, и это был рекорд,
а теперь 14171 и это ещё половина месяца не кончилась — видимо, какие-то изменения в сборе статистики (если прежний уровень не вернётся)
Wednesday, July 14, 2021
‘Inflammation clock’ can reveal body’s biological age
Using machine learning, researchers created a tool that might help doctors improve people’s healthy lifespan.
Max Kozlov
Healthy people can have a biological age lower than their chronological one.
A new type of age ‘clock’ can assess chronic inflammation to predict whether someone is at risk of developing age-related disorders such as cardiovascular and neurodegenerative disease. The clock measures ‘biological age’, which takes health into consideration and can be higher or lower than a person’s chronological age.
The inflammatory ageing clock (iAge), reported on 12 July in Nature Aging1, is one of the first tools of its kind to use inflammation to assess health. Other age clocks have used epigenetic markers, chemical groups that tag a person’s DNA as they age and are passed along as cells divide. The researchers who developed iAge hope that, because inflammation is treatable, the tool could help doctors determine who would benefit from intervention — potentially extending the number of years a person lives in good health.
The study “is a further reinforcement of the fact that the immune system is critical, not only for predicting unhealthy ageing, but also as a mechanism driving it”, says Vishwa Deep Dixit, an immunobiologist at Yale School of Medicine in New Haven, Connecticut, who was not involved in the work.
Keeping time
iAge is based on the idea that as a person ages, their body experiences chronic, systemic inflammation because their cells become damaged and emit inflammation-causing molecules. This ultimately leads to wear and tear on their tissues and organs. People who have a healthy immune system will be able to neutralize this inflammation to some extent, whereas others will age faster.
To develop iAge, a team including systems biologist David Furman and vascular specialist Nazish Sayed at Stanford University in California analysed blood samples from 1,001 people aged 8–96 who are part of the 1000 Immunomes Project, which aims to investigate how signatures of chronic, systemic inflammation change as people age. The researchers used the participants’ chronological ages and health information, combined with a machine-learning algorithm, to identify the protein markers in blood that most clearly signal systemic inflammation. In particular, they pinpointed the immune-signalling protein, or cytokine, CXCL9 as a top contributor; it is mainly produced by the inner lining of blood vessels and has been associated with the development of heart disease.
Sayed says that CXCL9 being a key component of iAge gives new credence to the adage that “you’re only as old as your arteries”.
After developing it, the researchers tested iAge by collecting the blood of 19 people who had lived to at least 99 years old, and using the tool to calculate their biological age. On average, the centenarians had an iAge 40 years lower than their actual age, according to a press release — aligning with the idea that people with healthier immune systems tend to live longer.
Ageing gracefully
Scientists have long explored the idea of age clocks as a predictor of how healthy a person currently is. Epigenetics-based research in this area has shown some promise2, but María Mittelbrunn, a molecular biologist at the Autonomous University of Madrid, says that evaluating a person’s biological age by measuring epigenetic changes to their DNA can be complicated. Measuring inflammation with a blood test would be easier, making a tool such as iAge more practical for a clinical setting.
Furman hopes that iAge and other age clocks based on inflammation might enable personalized treatments, too.
When examining CXCL9 as a biomarker of systemic inflammation, Furman and his colleagues grew human endothelial cells, which make up the walls of blood vessels, in a dish and artificially aged them by letting them divide repeatedly. The researchers saw that high levels of the protein drove the cells into a dysfunctional state. When the team silenced expression of the gene that encodes CXCL9, the cells regained some function, suggesting that the protein’s harmful effects might be reversible.
If caught early, “inflammation is one of the best things we can treat”, says Mittelbrunn. “We have developed amazing anti-inflammatory tools, so I think it’s a biological process that we have a lot of knowledge about and can target easily.” For instance, researchers have long known about salicylic acid (a starting material for making aspirin), and have more recently developed JAK/STAT inhibitors for inflammatory conditions such as rheumatoid arthritis .
Sayed envisions a future in which anyone can undergo inflammatory-biomarker profiling on a regular basis to keep tabs on their risk of developing age-related disease. “If we can control ageing in a more impactful way,” he says, “I think we can have a more graceful ageing process.”
doi: https://doi.org/10.1038/d41586-021-01915-x
Friday, February 19, 2021
zen vs blogger
- ФБ меня забанил,
- думал-думал (ссылка в РФ не сработает)
- завёл блог на zene (а это наоборот)
Кто более матери ценен?
Поживём увидим, как говорят слепые
Петрушка в ссылках: одна — рабочая, другая — нет, а болг-то должно быть глобальным, а не оральным, о котором сейчас много говорят. Сначала вписался, а теперь уже не могу — ну, и хер с ним. Я же не путен.
+ опыт с яндексом у меня уже был, и он меня так же прекрасно забанил. Потом уже ушол из ЖЖ, практически. Теперь гуголь на очереди. Не хотелось бы, но — см выше, как грят слепые.
пояснения 2хлетней давности, часть уже в прошлом:
February 19, 2018 ·
Самое страшное в блокировке на месяц, что с некоторыми важными людьми я был связан только в чате ФБ, а его тоже блокируют (это в прошлом). Но с помощью Дмитрий Борко, Владимир Варфоломеев , Boris Denisov, Veruška Volf все были оповещены, за что им всем большое спасибо.
Изучая не только из-за этого политику Фейсбука могу вас заверить, что Цукерберг окончательно охуел от монополизма и в дальнейшем все будет только хуже. Например, при наличии некоторых слов в тексте понижается его выдача в ленты (в ближайшее время вы будете видеть все меньше постов тов Аркадий Бабченко - подробности в комменте, а то понизят в выдаче), а теперь официально объявлено, что приоритет в выдаче будет для постов реальных друзей и членов семьи. Показ постов со страниц, на которые вы сами в здравом уме подписались, чтобы их читать, будет снижен с 5% до 4%.
Поэтому рекомендую читать ленту в Твиттере, там она формируется хронологически, а ссылка на пост в фб публикуется автоматически. Я там: https://twitter.com/hegtor
Wednesday, September 23, 2020
a week of the fb ban
fb personal
тут написано, за что забанили, за hate speech, btw — такшта: шутки в сторону
лучше бы дома сидели, но этто не только их касается
про хотелку, вместо которой растёт страшылка — как всегда и как лучше
про счёт пандемии, кто, как и что считает (из Nature, аднака)
пох оже, что таки единственная, куда перепись записана, и проводят уже больше 200 лет — самая длинная переписная история, Новый Свет btw
а у разнополых, практично у всех
завидуют все, но в тряпочку
про нехту и РБ
про смертность от ковида, но не в Швеции, а под оккупацией
тоже в связи с пандемией и гриппом.ру
влияние эпидемии на обращене к врачам, в частности. беременных
Researchers highlight ‘questionable’ data in Russian coronavirus vaccine trial results
и даже в области балета вакцины, да, чоуштам — ва всех
теплеет Восток и Север заодно
но нам нет приград, ни в суши, Нина Море
запишите на Ваш магнитофон: пенсии будут повышены выше инфляции
не пей кололоку, думай об Африке
хочешь мира — готовься к борьбе за него
с чего начали, туда же и вернулись: как нам обустроить РабКрИн
Friday, June 26, 2020
Demography is not limited
Demography science is not limited to the study of population distribution by age. Demographers can help elucidate other sources of between- and within-age variations in social distancing levels and infection, hospitalizations, and fatality rates as severe acute respiratory syndrome coronavirus 2 spreads in different settings. Besides chronic diseases, other potential factors include population density, household size and composition, hygienic and sanitary conditions, access to healthcare services, case notification systems, migration and displacement patterns, interregional inequalities, labor-market structure, economic disparities and welfare programs, endemic and other epidemic diseases, early-life conditions, epigenetic mechanisms, and immunosenescence.
Нам нет пре град — это, конечно, верно, но и шютка, с другой стороны
Будущее принадлежит не физике, а таким коротким и быстрым статьям на интернете (как по ссылке). Не знаю за физику, но демография, имхо, в струе, хотя скрепа крепка.
Будущее принадлежит не физике, а таким коротким и быстрым статьям на интернете (как по ссылке). Не знаю за физику, но демография, имхо, в струе, хотя скрепа крепка.
Monday, March 9, 2020
Wednesday, May 1, 2019
new record high
не знаю, почему так получилосьвидимо, в пару-тройку индексаций угодил
но новый рекорд
Tuesday, February 19, 2019
what a day !
Monday, February 11, 2019
Monday, January 7, 2019
Russian in England and Wales
вопрос вполне разумный возник вчера по поводу предыдущего поста
This dataset provides 2011 estimates that classify usual residents aged 3 and over in England and Wales by their main language. The estimates are as at census day, 27 March 2011.
This is the first time (как и в нашем случае) this information has been available from the census. Estimates are used to help central government, local authorities and the NHS allocate resources and provide services for non-English speakers. It also helps public service providers effectively target the delivery of their services. For example, translation and interpretation services and material in alternative languages.
This dataset provides 2011 estimates that classify usual residents aged 3 and over in England and Wales by their main language. The estimates are as at census day, 27 March 2011.
This is the first time (как и в нашем случае) this information has been available from the census. Estimates are used to help central government, local authorities and the NHS allocate resources and provide services for non-English speakers. It also helps public service providers effectively target the delivery of their services. For example, translation and interpretation services and material in alternative languages.
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